Our Episodes

Episode 126: AML Series, Pt 12 - Treatment of patients with relapsed/refractory disease 

This week, we round out our AML series with a detailed discussion about the approach to management of relapsed and refractory disease. This has been a VERY long road going through all management of AML. We hope that you have continued to build on our discussions week-to-week. An exciting treatment paradigm that is ever-evolving!

Episode 125: AML Series, Pt 11 - Treatment of patients unfit for intensive therapy

In today’s episode, we discuss how to approach AML treatment for patients who are unfit for intensive therapy.

Episode 124: AML Series, Pt 10 - Allogeneic transplant for AML

In today’s episode, we welcome back Dr. Amar Kelkar for part 2 of our two-part discussion on allogeneic transplant. In this episode, we build on our prior discussion regarding transplant, this time focusing on transplant for the treatment of AML.

Episode 123: AML Series, Pt 9 - Introduction to Allogeneic Transplant

In today’s episode, we welcome back Dr. Amar Kelkar for part 1 of our two-part discussion on allogeneic transplant. In this episode, we discuss the fundamental approach to patient selection and stem cell source selection. As you all know from this series, allogeneic transplants play a pivotal role in the management of AML. Dr. Kelkar’s pearls of wisdom help make this confusing topic so much more approachable!

Episode 122: AML Series, Pt 8 - AML Maintenance Therapies

This week, we continue our discussion on consolidation and maintenance therapies for AML, this focusing specifically on the maintenance component. This episode builds on our consolidations episodes (Ep. 120 and 121) so if you have not listened to this just yet, we highly recommend doing so!

Episode 121: AML Series, Pt 7 - AML Consolidation: Role of Allogeneic Transplant

This week, we continue our discussion on consolidation and maintenance therapies for AML, this time highlighting the role of allogeneic stem cell transplants. This episode builds on our prior episode, so if you have not listened to this just yet, we highly recommend doing so!

Episode 120: AML Series, Pt 6 - AML Consolidation: Therapeutic Approaches 

This week, we move to our next phases of therapy for AML, which are consolidation and maintenance. Be sure to check out our prior episodes for a discussion on initial workup and how we incorporate recurrent genetic abnormalities into how we think about AML. Check out figure 1 from this paper for a helpful diagram!

Episode 119: AML Series, Pt 5 - AML Induction: Options for Upfront Therapy 

This week, we round out our discussion regarding AML induction, this time focusing on the treatment options in the first line setting. We go through the various options, the dosing strategies, and the data behind them. 

Be sure to check out parts one and two of this three-part induction discussion, as we continue to build on these concepts! Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!

Episode 118: AML Series, Pt. 4 - AML Induction: Approach to Initial Management 

In this week’s episode, we continue onto part two of our three-part discussion on AML induction, this week focusing on selecting our up-front regimen. 

Be sure to check out last week’s episode, as this one builds on that one. Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!

Episode 117: AML Series, Pt. 3 - AML Induction: Definitions and Overview

In this week’s episode, we start our three-part discussion on AML induction, this week focusing on key definitions and an overview of treatment.

Also, if you have not done so, please do check out ourhemepath series to ensure you can more easily follow along with this conversation!

Episode 116: AML Series, Pt. 2 - MDS/AML Diagnosis and Risk Stratification

In this week’s episode, we discuss the diagnostic criteria and risk stratification for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), building on our discussion from last week. Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!

Episode contents:

- A review of what to look at on the bone marrow biopsy report

- WHO and ICC classification for AML and MDS

- Disease-defining cytogenetic markers to be aware of and their prognostic implications

Episode 115: AML Series, Pt. 1 - CHIP, CCUS, ICUS, oh my!

This week, we kick off a new series focusing on myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this first episode, we discuss the alphabet soup of premalignant hematologic conditions including CHIP, CCUS, and ICUS, before moving onto MDS and AML in future episodes.

By popular demand, our next series that we are excited to share with you is on MDS/AML! As we prepare for the release of the first episode next week, let’s throw it back to Episode 019 in our Heme/Onc Emergencies Series and talk about APL!

Episode 113: Sickle Cell Series - Chronic Management of Sickle Cell Disease

In this week’s episode, we discuss the management of sickle cell disease in the chronic setting. This is a follow up to episode 111 where we discussed acute management of SCD. And furthermore, this is also in addition to our prior discussion about long-term chronic complications from SCD in episode 110. We highly recommend checking out these prior episodes if you haven’t done so already!

Episode 112: Sickle Cell Series - Chronic Management of Sickle Cell Disease

In this week’s episode, we discuss the management of sickle cell disease in the chronic setting. This is a follow up to episode 111 where we discussed acute management of SCD. And furthermore, this is also in addition to our prior discussion about long-term chronic complications from SCD in episode 110. We highly recommend checking out these prior episodes if you haven’t done so already!

Episode 111: Sickle Cell Series - Acute Management of Sickle Cell Disease

In this week’s episode, we discuss the management of acute complications of sickle cell disease including acute pain episodes and acute chest syndrome as well as a discussion of hyperhemolytic syndrome.

Episode 110: Sickle Cell Series - Chronic Complications in Sickle Cell Disease

In this week’s episode, we discuss chronic complications that can arise in patients with sickle cell disease. The reality is, that unless we have an outpatient clinic or rotate through an outpatient clinic, there is a small chance that we will come across many of these issues. However, screening for and managing these chronic complications can have significant implications on our patients’ lives.

Episode 109: Sickle Cell Series - Introduction to Sickle Cell Disease

It’s time for another new series, this time focusing on Sickle Cell Disease! In this first episode, we lay the foundation for our future discussions. This episode can be dense, but rest assured we will revisit these concepts and expand on them throughout the series.

Episode 108: Colorectal Cancer Series, Pt. 10 - Metastatic Colorectal Cancer (Part 2)

This week, we round out our discussion on metastatic colorectal cancer, focusing on more targeted therapies for this disease. If you have not done so already, be sure to check out episode 107 for the first part of our metastatic colorectal cancer discussion.

Episode 107: Colorectal Cancer Series, Pt. 9 - Metastatic Colorectal Cancer (Part 1)

This week, we continue our discussion of colorectal cancer, turning our attention to metastatic disease, specifically for cancers without targetable mutations. If you have not done already, we highly recommend you check out episode 104 for our GI oncology pharmacology discussion!

An exciting new academic year is about to begin. We know this can be daunting, especially for our newest hematology/oncology fellows. Over the next two weeks, we re-boot some of our high yield episodes you need to know to prepare for your first days as a new fellow and your nights on call. 

Next up: Cord Compression [Originally episode 014]

An exciting new academic year is about to begin. We know this can be daunting, especially for our newest hematology/oncology fellows. Over the next two weeks, we re-boot some of our high yield episodes you need to know to prepare for your first days as a new fellow and your nights on call. 

Next up: SVC Syndrome [Originally episode 012]

An exciting new academic year is about to begin. We know this can be daunting, especially for our newest hematology/oncology fellows. Over the next two weeks, we re-boot some of our high yield episodes you need to know to prepare for your first days as a new fellow and your nights on call. 

Next up: Metastatic Cancer of “Origin TBD,” a common question that comes up on solid oncology consults! [Originally episode 008]

An exciting new academic year is about to begin. We know this can be daunting, especially for our newest hematology/oncology fellows. Over the next two weeks, we re-boot some of our high yield episodes you need to know to prepare for your first days as a new fellow and your nights on call.

Next up: immune thrombocytopenic purpura [Originally episode 015]

An exciting new academic year is about to begin. We know this can be daunting, especially for our newest hematology/oncology fellows. Over the next two weeks, we re-boot some of our high yield episodes you need to know to prepare for your first days as a new fellow and your nights on call.

First up: thrombotic thrombocytopenic purpura (TTP) [Originally episode 018]

Episode 106: Colorectal Cancer Series, Pt. 8 - Early Onset Colorectal Cancer

In a recent American Cancer Society publication, there are increasing data that rates of colorectal cancer are rising rapidly among people in their 20s, 30s and 40s. This has certainly caught the attention of the lay press, most recently in a widely circulated New York Times article published in March 2024. Today, we welcome Dr. Chris Cann, who is an Assistant Professor of Hematology/Oncology at the Fox Chase Cancer Center in Philadelphia where he focuses on GI oncology and has a particular area of interest in early onset colorectal cancer. In his short career thus far, Dr. Cann is already making a name for himself in this space on a national level and so we are so glad he was able to join us for this special discussion. Dr. Cann sheds light on what we know and what we don’t know about this phenomenon. Definitely an episode to check out!

Episode 105: Colorectal Cancer Series, Pt. 7 - Management of Rectal Cancer

This week, we incorporate medical oncology back into our discussion with our Radiation Oncologist, Dr. Sanford, and our Surgical Oncologist, Dr. Bailey. We discuss how we approach the management of localized rectal cancer. Note that we will be heavily building off our discussions with our specialist. We recommend listening to these episodes if you have not done so already.